Intra-articular injection of Torin 1 reduces degeneration of articular cartilage in a rabbit osteoarthritis model
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چکیده
منابع مشابه
Intra-articular injection of Torin 1 reduces degeneration of articular cartilage in a rabbit osteoarthritis model
OBJECTIVES Recent studies have shown that systemic injection of rapamycin can prevent the development of osteoarthritis (OA)-like changes in human chondrocytes and reduce the severity of experimental OA. However, the systemic injection of rapamycin leads to many side effects. The purpose of this study was to determine the effects of intra-articular injection of Torin 1, which as a specific inhi...
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BACKGROUND To investigate the effects of AOD9604 intra-articular injections with or without hyaluronic acid (HA) in a collagenase-induced knee osteoarthritis (OA) rabbit model. DESIGN Mature New Zealand white rabbits (n=32) were randomly administered 2 mg collagenase type II twice in each knee joint. Weekly injections of 0.6 mL saline (Group 1), 6 mg HA (Group 2), 0.25 mg AOD9604 (Group 3), a...
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ژورنال
عنوان ژورنال: Bone & Joint Research
سال: 2016
ISSN: 2046-3758
DOI: 10.1302/2046-3758.56.bjr-2015-0001